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KMID : 0358819910180040626
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1991 Volume.18 No. 4 p.626 ~ p.632
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THE EFFECTS OF SUPEROXIDE DISMUTASE ON ISCHEMIC REVASCULARIZED MUSCLE IN RATS
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Abstract
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Superoxide radicals have been shown to play an important role in the cellular injury of reperfused ischemic tissue.
We examined the protective effect of superoxide dismutase(SOD), one of the derivatives of superoxide radical scavengers, on the reperfusion injury of replanted rat limb with 6-hour ischemic period.
Biochemically, the amounts of superoxide radicals in ischemic hind limbs treated with SOD have decreased significantly compared to those of control group.(p<0.01)
Histologically, SOD treated extremities demonstrated less inflammatory reaction and degenerative change than control group.
Our results indicate that the administration of SOD to a amputation part by means of intra arterial perfusion after prolonged period of warm ischemia significantly decreases the tissue damage.
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